Showing posts with label toxicity: marijuana. Show all posts
Showing posts with label toxicity: marijuana. Show all posts

Thursday, December 18, 2014

Reefer Madness: the 2014 Marijuana Update






As a teenager in Cary, I distinctly remember being shown the cult film, Reefer Madness (1936), in Health Class as a deterrent to trying marijuana. The film had a distinct scare factor at the time. As time passed, it morphed into more silliness than fact. To drive the point home, a sample of artificial marijuana was produced and lit to discourage use by my classmates. I am not sure it helped. During the session, while the teacher was distracted one classmate, Curtis, began hanging out the window (2 stories up). Then he sneaked out the door, went down the stairs, and proceeded to lie on the ground below the window. Then classmates yelled, “Curtis just fell out the window," of course he didn’t, but the teacher was not in on the joke.
 The movie was on my mind at a recent lecture by Dr. Dawn Boothe from Auburn University into new points into the science of medical marijuana. As several states have decriminalized recreational use, there has been a huge upswing in dogs ingesting recreational forms. The focus of this blog is the medical application of the more that 480 unique compounds it contains. 
HOW LONG HAS MARIJUANA BEEN AROUND?
It has been part of recreational, religious, and medical activities for a variety of cultures for over 5000 years. Interestingly, marijuana was one of the more commonly prescribed medications in the USA until it was declared illegal in the 1930’s.  Due to its control of pain, many states have passed laws that allowed medical use in people. There is little to no research of benefits in pets.  Marijuana is still illegal on the federal level.
HOW DOES ONE KNOW Street POT’s STRENGTH? 
You do not know as it can vary depending on how much of what plant part is contained, the quantity consumed, sex, age, grown indoors vs outdoors, when harvested, and how it is dried/stored. 
WHAT ARE THE PHYSIOLOGICAL EFFECTS OF MARIJUANA?
Problems with memory and learning, red eyes, distorted perception, difficulty thinking and problem solving, incoordination, increased heart rate, and panic attacks. The tolerance varies between people, and withdrawal leads to nervousness, restlessness, anxiety, and insomnia. Concerns in teenage use include lower IQ’s and depression. 
WHAT ARE THE TOUTED BENEFITS/MEDICAL TREATMENTS OF MEDICAL MARIJUANA?
THC, the most active component, is a muscle relaxant, ant-inflammatory, anti-depressant, increases appetite, and stimulant. Other components (CBD, CBC, and CBG) are touted for treatment of behavioral, sleep disorders, protection of the nervous system, ant-anxiety (think valium-like), bone healing, nausea, glaucoma, diabetes, suppression of the immune system, malaria, and pain control.

Memphis , proudly owned by Jon & Jane Woodall



There is NO DATA to support this broad appeal in pets and limited in people. The smoke/lung cancer risks of inhaled forms are not widely discussed.  Marijuana is still illegal on the federal level.


ARE THERE legal, PRESCRIPTION FORMS OF MARIJUANA AVAILABLE AT HUMAN PHARMACIES? If so, what are its benefits compared to the marijuana dispensary? 
Yes, Marinol (dronabinol) is a synthetic THC prescription medication form of marijuana that has been out for 30 years.  The benefits are that  this is a narrow spectrum compound versus smoking marijuana, which contains a wide variety “buffet line” of chemical components. Marinol is used to treat nausea, vomiting, and stimulate appetite, all of which are side effects of chemotherapy, when other treatments are unsuccessful. Cost on the goodRx site in Cary, NC average about $10 per tablet. 
Epidiolex (a version of marihuana lacking THC) is used for seizures with other measures have failed. 
ARE MOST MEDICAL MARIJUAHUA DISPENSORIES PRESCRIBING MEDICAL MARIHUAHA UNDER THE ADVICE OF A BOARDED SPECIALIST (FOR EXAMPLE ASTHMA)?
No, it appears most prescriptions are from doctors that are general practitioners, and security of those prescriptions was lax due to the lack of money and coordination with the Federal government. Yet, the costs are higher to consumers to obtain medical marihuana from dispensaries (government taxes) rather than traditional pharmacies. 
STAY TUNED AS MARIJUANA STUDIES ARE BEING CONTEMPLATED FOR PAIN CONTROL IN PETS. 
As a side note, from the nutritional talks and lots of options after the scare from the melamine and the wheat gluten scare around 2007, what happened to the Food and Drug czar in China? Well in China, Zheng Xiaoyu: China Ex-Food and Drug Safety Chief WAS Sentenced to Death. http://www.mindfully.org/Industry/2007/Zheng-Xiaoyu-China29may07.htm


Dakota, owned by Dave Bubb
Sigmon DVM, Diplomate ABVP canine & feline
Creature Comforts Animal Hospital
Cary, NC

Thursday, March 13, 2014

Fishing for the Source of Suspected Toxicity




Sunday morning – I witness a beautiful sunrise even though it is late with Daylight Saving’s time. Taco Belle is exploring the hellebores, daffodils, and flowering quince that are projecting their subtle beauty to a world that has been previously encrusted with sleet, snow, and bone chilling rain for the past month.



In my morning quiet time I remembered a time long ago when my husband and I took Jason fishing. It was a glorious day, and I witnessed the delight of a child in discovering the mystery of what was on the other end of the fishing pole. When my husband, a fisherman for over 50 years, suggested he try the other side of the boat, he says, "My philosophy is to cast here.” Thus one day of fishing experience for a child superseded that of a half century by a parent.




At the start of each day I personally ask the Creator of this magnificent universe for wisdom in my approach to the day. It truly is a privilege to be entrusted with the care of your precious dogs and cats.
The humbling reality is, unlike humans, pets cannot tell us where they have been and what the cause might be of their illness. "Fishing" for a cause and appropriate treatment is at times quite a frustration. Dr. Mackie, my dear friend, NCSU cohort, and veterinary colleague for over 33 years ( the last 6 at Creature Comforts Animal Hospital), lamented the other day that we occasionally remember our successes but are forever haunted by our failures. And one of the most tormenting failures we encounter is when a pet is ill due to toxic ingestion of prescription and recreational drugs, plants, pesticides, and poisons. I thought I would take this moment to answer some common questions about this topic, and hopefully reduce the number of toxicity cases I see.  


What is one of the toxicities on the rise in the veterinary profession?
Marijuana (Cannabis sativa) ingestion is being noted nationwide, not just in states such as Colorado and Washington where “weed” is legalized.  NBC news reports the Animal Poison Control Center has reported a 30% rise. Since dogs weigh less than people, marijuana can sit in “stoned” pets for 3 to 4 days and cause dilated pupils, red eyes,  drooling,  urinary incontinence, low body temperature, disorientation/drunken appearance, slow heart rate, seizures, and in rare cases coma. The edible "pot" signs are related to amount of THC weed consumed versus the weight of the animal. 25% do not react in the same manner as people; rather they become agitated, distressed, and have rapid heart rates. Signs can develop within 30 to 60 minutes after ingestion as it targets the brain.  
How do pets consume such products?
 Ingestion comes from leaves, edible products, and Bong water. The edible versions are made the same as regular cookies or brownies with the cannabis oil added to the recipe. Although these contain high levels of the chief psychoactive substance, tetrahydrocannabinol, THC, they taste the same as the regular product. Tainted versions for sale also include beef jerky, chai mints, and chocolate truffles. People practice restraint and tend to eat one brownie; while dogs engorge on the “entire box” of tainted goodies. When there is a lot of chocolate in the product, this can enhance the toxicity signs. THC also seems to increase the “munchies” tendency.
Is there an antidote for ingestion of marijuana?
No, supportive care is given with warm fluids to help maintain normal body temperature, monitor blood pressure,  activated charcoal administered orally to lower the amount of absorption, and induction of vomiting if within a couple of hours of ingestion.  Many pets will require supervision for 3 to 4 days in a hospital setting necessary for those showing seizures or extreme intoxication. However, since marijuana is used for the medicinal purpose to lessen nausea associated with chemotherapy in people, it can be a challenge to induce vomiting after ingestion.
I found a ½ empty baggy with a green, leafy substance in my child’s room and my pet is acting disoriented. How can I document this is marijuana exposure?



Take your pet and the substance to a veterinary facility. It is not a reportable issue to legal authorities. Rather the concern is the health and safety of your pet. Blood and urine tests to human laboratories such as Lab Corp are recommended. Although there are over the counter urine test kits, pets often test falsely negative. In people, these urine tests often cross react positive  with human medications such as antibiotics, anti-anxiety drugs, pain, and cold medications, so self-diagnosis is not recommended.
Can pets die from marijuana ingestion? Where can I obtain emergency information quickly?
Yes, but this is rare.  Please call the front desk during office hours at 919-387-3435 for emergency help. As an alternative, The Pet poison hotline is available at 1-800-213-6680 for emergency questions (iPhone app $1.99). There is a $39 fee charge. Be truthful in  these conversations concerning the risks of exposure including prescription & recreational drugs as well as possible indoor & outdoor poisons.  We are “fishing together, “not playing charades.

One, highlight of this blog I would like to add is searching the internet for new research that is helpful to all of us. Below is one such research proposal at Auburn University released this week concerning fibroids in women.
Why is this research proposal an interesting investigation for women’s health?
Auburn University reports that 70% of women in the USA will develop uterine fibroids by 50 years of age which can be painful and debilitating. The cause (and thus effective treatment) remains elusive. In utilizing a hens laying eggs model, investigators are researching over-nutrition and onset of early puberty. According to Dr. Wallace Berry, poultry scientist at Auburn, chickens have ovarian cells and hormonal cycles that are similar to women. In a controlled setting, researchers can manipulate the sexual development of hens through lighting and diet. One hypothesized factor is the rising insulin growth factor (IGF) factor which increases with over-nutrition, leading to an increased risk of fibroid tumors. In summary, this research project could help establish ways to lessen the severity of uterine fibroid tumors through nutritional recommendations. One third of the 600,000 hysterectomies performed in the USA are due to fibroid tumors.
Statically and fiscally speaking, besides the physical & mental toll on women and their families, the annual cost of lost work hours, surgeries, hospitalizations, lost work hours, and pregnancy complications due to uterine fibroid tumors is estimated by Auburn at $34.4 billion dollars annually.
On a personal note, my mother died from complications of uterine cancer when I was 25 years old. Having a sister that was recently diagnosed and treated for uterine cancer, it is personal as well.
Until next time,


Betsy Sigmon DVM , hospital director, Creature Comforts Animal Hospital, Cary, NC